FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis
Recent evidences have highlighted that the pituitary hormones have profound effects on bone, so that the pituitary-bone axis is now becoming an important issue in the skeletal biology. Here, we discuss the topical evidence about the dysfunction of the pituitary-bone axis that leads to osteoporotic b...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/382698 |
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| author | Graziana Colaianni Concetta Cuscito Silvia Colucci |
| author_facet | Graziana Colaianni Concetta Cuscito Silvia Colucci |
| author_sort | Graziana Colaianni |
| collection | DOAJ |
| description | Recent evidences have highlighted that the pituitary hormones have profound effects on bone, so that the pituitary-bone axis is now becoming an important issue in the skeletal biology. Here, we discuss the topical evidence about the dysfunction of the pituitary-bone axis that leads to osteoporotic bone loss. We will explore the context of FSH and TSH hormones arguing their direct or indirect role in bone loss. In addition, we will focus on the knowledge that both FSH and TSH have influence on proinflammatory and proosteoclastogenic cytokine expression, such as TNFα and IL-1, underlining the correlation of pituitary-bone axis to the immune system. |
| format | Article |
| id | doaj-art-216efce4e687442fb537918e8423ab2d |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-216efce4e687442fb537918e8423ab2d2025-02-03T01:24:25ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/382698382698FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone AxisGraziana Colaianni0Concetta Cuscito1Silvia Colucci2Department of Basic Medical Sciences, Neuroscience and Sense Organs, Section of Human Anatomy and Histology, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, Section of Human Anatomy and Histology, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, Section of Human Anatomy and Histology, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyRecent evidences have highlighted that the pituitary hormones have profound effects on bone, so that the pituitary-bone axis is now becoming an important issue in the skeletal biology. Here, we discuss the topical evidence about the dysfunction of the pituitary-bone axis that leads to osteoporotic bone loss. We will explore the context of FSH and TSH hormones arguing their direct or indirect role in bone loss. In addition, we will focus on the knowledge that both FSH and TSH have influence on proinflammatory and proosteoclastogenic cytokine expression, such as TNFα and IL-1, underlining the correlation of pituitary-bone axis to the immune system.http://dx.doi.org/10.1155/2013/382698 |
| spellingShingle | Graziana Colaianni Concetta Cuscito Silvia Colucci FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis Clinical and Developmental Immunology |
| title | FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis |
| title_full | FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis |
| title_fullStr | FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis |
| title_full_unstemmed | FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis |
| title_short | FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis |
| title_sort | fsh and tsh in the regulation of bone mass the pituitary immune bone axis |
| url | http://dx.doi.org/10.1155/2013/382698 |
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