Trichinella spiralis adult excretory-secretory antigen promotes peripheral regulatory T cell differentiation and attenuates experimental colitis via TGF-β-like mechanisms

Trichinella spiralis adult excretory-secretory antigen promotes peripheral regulatory T cell differentiation and attenuates experimental colitis via TGF-β-like mechanisms

Abstract Background Trichinella spiralis adult excretory-secretory antigen (TsAES) has been proposed as a potential immunomodulator capable of promoting naïve T cell differentiation into peripheral regulatory T cells (pTregs). This study aims to investigate the effects of TsAES on pTreg development...

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Bibliographic Details
Main Authors: Xi-Meng Sun, Ze-Ni Luo, Wei Wang, Chun-Yue Hao, Zhi-Ang Li, Saeed El-Ashram, Xin-Ping Zhu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Parasites & Vectors
Subjects:
Trichinella spiralis
Adult excretory–secretory antigen
Regulatory T cells
Colitis
Online Access:https://doi.org/10.1186/s13071-025-06877-x
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https://doi.org/10.1186/s13071-025-06877-x

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