Serine-Driven Metabolic Plasticity Drives Adaptive Resilience in Pancreatic Cancer Cells

Serine-Driven Metabolic Plasticity Drives Adaptive Resilience in Pancreatic Cancer Cells

Pancreatic cancer is one of the most lethal malignancies, in part due to its profound metabolic adaptability, which underlies drug resistance and therapeutic failure. This study explores the metabolic rewiring associated with resistance to treatment using a systems metabolomics approach. Exposure to...

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Main Authors: Marcella Bonanomi, Sara Mallia, Mariafrancesca Scalise, Tecla Aramini, Federica Baldassari, Elisa Brivio, Federica Conte, Alessia Lo Dico, Matteo Bonas, Danilo Porro, Cesare Indiveri, Christian M. Metallo, Daniela Gaglio
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Antioxidants
Subjects:
pancreatic cancer
drug resistance
serine metabolism
metabolic rewiring
targeted therapy
Online Access:https://www.mdpi.com/2076-3921/14/7/833
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