How to manage hypersensitivity reactions to enzyme replacement therapy in lysosomal storage diseases?

Abstract Lysosomal Storage Diseases (LSDs) encompass a range of genetic disorders characterized by enzyme deficiencies that lead to substrate accumulation and progressive tissue damage. Enzyme Replacement Therapy (ERT) is the primary treatment for LSDs, yet it is often associated with hypersensitivi...

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Bibliographic Details
Main Authors: Federico Spataro, Antonio Giovanni Solimando, Vanessa Desantis, Angelo Vacca, Attilio Di Girolamo, Roberto Ria
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Orphanet Journal of Rare Diseases
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Online Access:https://doi.org/10.1186/s13023-025-03844-8
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