INVESTIGATION OF CANDIDATE GENE POLYMORPHISMS IN AN IMMUNE RESPONSE AS MARKERS FOR THE RISK OF DEVELOPING RHEUMATOID ARTHRITIS AND PRODUCING AUTOANTIBODIES

INVESTIGATION OF CANDIDATE GENE POLYMORPHISMS IN AN IMMUNE RESPONSE AS MARKERS FOR THE RISK OF DEVELOPING RHEUMATOID ARTHRITIS AND PRODUCING AUTOANTIBODIES

Objective: to investigate the distribution of the genotypes and alleles of the PTPN22, TNFAIP3, CTLA4, TNFA, IL6, IL6R, IL10, MCP1, and ICAM1 genes in patients with rheumatoid arthritis (RA) and in the control group of healthy individuals, to estimate their significance as molecular genetic markers...

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Main Authors: I. A. Guseva, N. V. Demidova, N. E. Soroka, E. L. Luchikhina, A. A. Novikov, E. N. Aleksandrova, G. V. Lukina, E. V. Fedorenko, E. S. Aronova, E. Yu. Samarkina, D. Yu. Trofimov, D. E. Karateev, E. L. Nasonov
Format: Article
Language:Russian
Published: IMA PRESS LLC 2016-03-01
Series:Научно-практическая ревматология
Subjects:
early rheumatoid arthritis
gene polymorphisms
single-nucleotide polymorphism
anti-cyclic citrullinated peptide antibodies
rheumatoid factor
Online Access:https://rsp.mediar-press.net/rsp/article/view/2165
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