Imbalanced mitochondrial dynamics in human PD and α-synuclein mouse brains

Imbalanced mitochondrial dynamics in human PD and α-synuclein mouse brains

Emerging studies have shown that dysregulation in mitochondrial dynamics has a major negative impact on mitochondria. Partial genetic and pharmacological inhibition of the mitochondrial fission dynamin-related protein 1 (DRP1) has been demonstrated to be beneficial in models of neurodegenerative dis...

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Bibliographic Details
Main Authors: Harry J. Brown, Rebecca Z. Fan, Riley Bell, Said S. Salehe, Carlos Martínez Martínez, Yanhao Lai, Kim Tieu
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
α-synuclein
Dynamin-related protein 1
Mitochondrial dynamics
Protein aggregation
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125001925
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