A cell-free SHED lysate-hydrogel system for oral ulcer healing with anti-inflammatory and pro-angiogenic effects

A cell-free SHED lysate-hydrogel system for oral ulcer healing with anti-inflammatory and pro-angiogenic effects

Abstract Oral ulcer (OU) is one of the most common mucosal diseases, yet current drug treatments yield unsatisfactory outcomes. Persistent inflammatory responses and insufficient angiogenesis are the two major obstacles to OU healing. Recently, stem cell-based therapies, particularly mesenchymal ste...

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Main Authors: Na Dong, Chen Zhang, Qiao Zhang, Sa Bao, Yunfan Hu, Haichao Xu, Peng Dai, Caiyan Li, Shengcun Li, Ping Wu, Junpeng Xu, Xiaojun Cai, Zhouguang Wang, Lihua Luo
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Oral ulcer
Stem cells from human exfoliated deciduous teeth
Cell lysate
Inflammatory response
Angiogenesis
Online Access:https://doi.org/10.1186/s12951-025-03597-3
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https://doi.org/10.1186/s12951-025-03597-3

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