Prevalence and prognostic impact of BRAF V600E mutation and CDKN2A deletion in pediatric high-grade glioma

Prevalence and prognostic impact of BRAF V600E mutation and CDKN2A deletion in pediatric high-grade glioma

Background and aimPediatric high-grade glioma (pHGG) is a rare and challenging disease with dismal outcomes. Identifying prognostic markers and targeted therapeutic avenues is crucial.MethodsWe conducted a retrospective study involving 130 pediatric patients with HGG treated at the Children’s Cancer...

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Main Authors: Soha Karim, Amal Mosaab, Hala Taha, Iman Naguib, Amal Refaat, Eslam Maher, Mohamed Saad Zaghloul, Mohamed El-Beltagy, Hanafy Hafez, Mohamed Kamal, Sherine Salem, Mark W. Kieran, Ahmed El-Hemaly, Alaa El-Haddad
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
pediatric
high grade
glioma
BRAF
CDKN2A
prevalence
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1537268/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1537268/full

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