Modular assembly and immunological evaluation of a promising bioconjugate nanovaccine against Klebsiella pneumoniae O2 serotype

Modular assembly and immunological evaluation of a promising bioconjugate nanovaccine against Klebsiella pneumoniae O2 serotype

Abstract The antimicrobial-resistant (AMR) Klebsiella pneumoniae (Kp) poses an enormous threat to human health, with O2 serotypes accounting for up to 35–59% of infections. Although the O-polysaccharide (OPS) of the Kp O2 serotype can be used as an antigen target for vaccine preparation, its simple...

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Main Authors: Peng Sun, Chao Pan, Huifang Xu, Bo Liu, Jingqin Ye, Kangfeng Wang, Yan Zhang, Ting Li, Li Zhu, Yating Wang, Hengliang Wang, Jun Wu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01187-w
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https://doi.org/10.1038/s41541-025-01187-w

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