Mitigating matrix effects for LC-MS/MS quantification of nitrosamine impurities in rifampin and rifapentine
Since the discovery of potentially mutagenic nitrosamine impurities in pharmaceuticals in 2018, liquid chromatography-mass spectrometry (LC-MS) methods have been widely applied for the trace level quantification of nitrosamines. As more nitrosamines and drug samples are analyzed, method accuracy is...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
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| Series: | Journal of Pharmaceutical and Biomedical Analysis Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949771X24000033 |
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