MiR221/222 in the conditioned medium of adipose-derived stem cells attenuates particulate matter and high-fat diet-induced cardiac apoptosis

MiR221/222 in the conditioned medium of adipose-derived stem cells attenuates particulate matter and high-fat diet-induced cardiac apoptosis

Abstract Background Air pollution and obesity are crucial risk factors for cardiovascular disease (CVD), with epidemiological evidence indicating that air pollution exacerbates obesity-induced cardiac damage. Treatment with adipose-derived stem cells (ADSCs) attenuates cardiac damage by releasing pa...

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Main Authors: Ya-Chun Chen, Chi-Ming Pu, Shu-Rung Lin, Shu-Wha Lin, I-Shing Yu, Ho-Jun Shih, Chiang-Wen Lee, Ming-Hsueh Lee, Yen-Ting Kuo, Yuh-Lien Chen
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Stem Cell Research & Therapy
Subjects:
Particulate matter (PM)
Palmitic acid (PA)
High-fat diet (HFD)
Conditioned medium from cultured adipose-derived stem cell (ADSC-CM)
miR221/222
Reactive oxygen species (ROS)
Online Access:https://doi.org/10.1186/s13287-025-04381-8
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https://doi.org/10.1186/s13287-025-04381-8

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