Elucidation of the anti-arthritic mechanism of Guizhi-Shaoyao-Zhimu decoction by reshaping circadian rhythm

Elucidation of the anti-arthritic mechanism of Guizhi-Shaoyao-Zhimu decoction by reshaping circadian rhythm

Rheumatoid Arthritis (RA) exhibits pronounced circadian oscillations, with variations in joint stiffness, pain, and swelling following rhythmic patterns. Our preliminary research suggests that inflammatory cytokines in RA serum display rhythmicity closely associated with circadian rhythms. Additiona...

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Main Authors: Xizi He, Runze Li, Xiaohong He, Fan He, Yao Xiao, Xianghong Chen, Yu Lai, Wanyi Guo, Peiyu Liu, Xiao Cai, Xiaonan Yang, Yongkang Shu, Jie Shao, Yulian Chen, Danli Chen, Minqi Quan, Jiaqi Wu, Leyao Xian, Jiayan He, Hong Ren, Zhengmin Chen, Zishao Zhong, Liang Liu, Hudan Pan
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Pharmacological Research
Subjects:
Rheumatoid Arthritis
Guizhi-Shaoyao-Zhimu Decoction
Circadian Rhythm
Immune Homeostasis
Biological Clock Gene
NR1D1
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825002129
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