Genistein inhibits HIF-1α and attenuates high glucose-induced peritoneal mesothelial-mesenchymal transition and fibrosis via the mTOR/OGT pathway

Genistein inhibits HIF-1α and attenuates high glucose-induced peritoneal mesothelial-mesenchymal transition and fibrosis via the mTOR/OGT pathway

Abstract Peritoneal fibrosis has been linked to hypoxia-inducible factor 1-alpha (HIF-1α) as well as O-linked-N-acetylglucosaminylation (O-GlcNAcylation) in peritoneal dialysis (PD). Genistein, recognized for its HIF-1α inhibitory and antifibrotic effects, presents a potential intervention against p...

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Bibliographic Details
Main Authors: Jian Wang, Xin Lv, Yao Lin, Ashanjiang Aniwan, Hongyan Liu, Saijun Zhou, Pei Yu
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Peritoneal dialysis
Genistein
HIF-1α
mTOR
O-GlcNAcylation
Fibrosis
Online Access:https://doi.org/10.1038/s41598-024-74879-3
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https://doi.org/10.1038/s41598-024-74879-3

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