The tumour sink effect on 68Ga-PSMA-PET/CT in metastatic castration-resistant prostate cancer and its implications for PSMA-RPT: a sub-analysis of the 3TMPO study

The tumour sink effect on 68Ga-PSMA-PET/CT in metastatic castration-resistant prostate cancer and its implications for PSMA-RPT: a sub-analysis of the 3TMPO study

Abstract Background The tumour sink effect is a phenomenon whereby the sequestration of a radiopharmaceutical in cancer lesions leads to decreased activity concentration in the blood stream and organs. The aim of this sub-analysis of the prospective 3TMPO study (NCT04000776) was to investigate the t...

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Main Authors: Atefeh Zamanian, Étienne Rousseau, François-Alexandre Buteau, Frédéric Arsenault, Alexis Beaulieu, Geneviève April, Daniel Juneau, Nicolas Plouznikoff, Éric E. Turcotte, Catherine Allard, Patrick O. Richard, Fred Saad, Brigitte Guérin, Frédéric Pouliot, Jean-Mathieu Beauregard
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Imaging
Subjects:
PET/CT
Prostate cancer
Prostate-specific membrane antigen (PSMA)
Radiopharmaceutical therapy
Sink effect
PSMA-617
Online Access:https://doi.org/10.1186/s40644-025-00910-z
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https://doi.org/10.1186/s40644-025-00910-z

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