Leishmania major Dihydrolipoyl dehydrogenase (DLD) is a key metabolic enzyme that drives parasite proliferation, pathology and host immune response.

Leishmania major Dihydrolipoyl dehydrogenase (DLD) is a key metabolic enzyme that drives parasite proliferation, pathology and host immune response.

Identifying antigens that elicit protective immunity is pivotal for developing effective vaccines and therapeutics against cutaneous leishmaniasis. Dihydrolipoyl dehydrogenase (DLD), a mitochondrial enzyme involved in oxidizing lipoamides to facilitate electron transfer for energy production and met...

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Main Authors: Somtochukwu S Onwah, Zhirong Mou, Gaurav Gupta, Patience Obi, Nnamdi Ikeogu, Ping Jia, Wen-Wei Zhang, Saeid Ghavami, Ayesha Saleem, Jude Uzonna
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012978
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https://doi.org/10.1371/journal.ppat.1012978

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