DEPDC5 regulates the strength of excitatory synaptic transmission by interacting with ubiquitin-specific protease 46

DEPDC5 regulates the strength of excitatory synaptic transmission by interacting with ubiquitin-specific protease 46

DEP-domain containing-5 (DEPDC5) is part of the GATOR1 complex that inhibits the mechanistic target of rapamycin complex-1 (mTORC1). Loss-of-function mutations in human DEPDC5 are the most common cause of lesional or non-lesional focal epilepsies associated with mTOR hyperactivation. Depdc5 silencin...

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Bibliographic Details
Main Authors: Maria Sabina Cerullo, Caterina Canevari, Antonella Marte, Alexandre Bacq, Antonio De Fusco, Marina Maletic, Stéphanie Baulac, Fabio Benfenati
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Neurobiology of Disease
Subjects:
Depdc5 mutations
DEPDC5 interactome
AMPA receptors
Deubiquitination
Excitatory synaptic strength
Primary neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002013
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http://www.sciencedirect.com/science/article/pii/S0969996125002013

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