Physicochemical investigation of phenobarbital sodium interactions with anionic bile salt micelles: Binding, partitioning, and micellization behavior
Understanding drug-surfactant interactions is crucial for optimizing pharmaceutical formulations. This study aimed to comprehensively investigate the physicochemical interactions between phenobarbital sodium (PS) and two anionic bile salts, sodium cholate (NaC) and sodium deoxycholate (NaDC), in aqu...
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Elsevier
2025-07-01
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| Series: | Next Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949822825003922 |
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| _version_ | 1849417531278753792 |
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| author | Haytham Abuissa Ashraf EL-Hashani |
| author_facet | Haytham Abuissa Ashraf EL-Hashani |
| author_sort | Haytham Abuissa |
| collection | DOAJ |
| description | Understanding drug-surfactant interactions is crucial for optimizing pharmaceutical formulations. This study aimed to comprehensively investigate the physicochemical interactions between phenobarbital sodium (PS) and two anionic bile salts, sodium cholate (NaC) and sodium deoxycholate (NaDC), in aqueous media. UV-Vis spectroscopy, conductivity, surface tension, and viscosity measurements were employed to determine critical micelle concentration (CMC), binding constants (Kb), partition coefficients (Kx), interfacial parameters, and thermodynamic functions. Key results show PS significantly reduced the CMC of both bile salts (NaC: 1.30 ×10⁻⁴ M; NaDC: 1.92 ×10⁻⁵ M). NaDC consistently demonstrated superior surface activity (e.g., Γmax = 1.958 µmol·m⁻², pC20 = 4.81) and more favorable thermodynamics for micellization (ΔG°m = −64.79 kJ/mol) and adsorption (ΔG°ads = −78.17 kJ/mol) compared to NaC. Furthermore, NaDC exhibited significantly stronger PS binding (Kb ≈ 1.44 ×10⁶ M⁻¹) and partitioning (Kx ≈ 2.85 ×10⁶), encapsulating ∼14 times more PS molecules per micelle than NaC. In conclusion, NaDC's enhanced hydrophobicity leads to superior micellization, drug binding, and solubilization capabilities, highlighting its considerable potential as an effective biosurfactant carrier for phenobarbital in pharmaceutical applications, offering valuable insights for drug delivery design. |
| format | Article |
| id | doaj-art-20cce00a8c344d2f83e25700b134f994 |
| institution | Kabale University |
| issn | 2949-8228 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Next Materials |
| spelling | doaj-art-20cce00a8c344d2f83e25700b134f9942025-08-20T03:32:47ZengElsevierNext Materials2949-82282025-07-01810087410.1016/j.nxmate.2025.100874Physicochemical investigation of phenobarbital sodium interactions with anionic bile salt micelles: Binding, partitioning, and micellization behaviorHaytham Abuissa0Ashraf EL-Hashani1Chemistry Department, Faculty of Arts and Science, Gheminus, Benghazi University, Gheminus, LibyaChemistry Department, Faculty of Science, Benghazi University, Benghazi, Libya; Corresponding author.Understanding drug-surfactant interactions is crucial for optimizing pharmaceutical formulations. This study aimed to comprehensively investigate the physicochemical interactions between phenobarbital sodium (PS) and two anionic bile salts, sodium cholate (NaC) and sodium deoxycholate (NaDC), in aqueous media. UV-Vis spectroscopy, conductivity, surface tension, and viscosity measurements were employed to determine critical micelle concentration (CMC), binding constants (Kb), partition coefficients (Kx), interfacial parameters, and thermodynamic functions. Key results show PS significantly reduced the CMC of both bile salts (NaC: 1.30 ×10⁻⁴ M; NaDC: 1.92 ×10⁻⁵ M). NaDC consistently demonstrated superior surface activity (e.g., Γmax = 1.958 µmol·m⁻², pC20 = 4.81) and more favorable thermodynamics for micellization (ΔG°m = −64.79 kJ/mol) and adsorption (ΔG°ads = −78.17 kJ/mol) compared to NaC. Furthermore, NaDC exhibited significantly stronger PS binding (Kb ≈ 1.44 ×10⁶ M⁻¹) and partitioning (Kx ≈ 2.85 ×10⁶), encapsulating ∼14 times more PS molecules per micelle than NaC. In conclusion, NaDC's enhanced hydrophobicity leads to superior micellization, drug binding, and solubilization capabilities, highlighting its considerable potential as an effective biosurfactant carrier for phenobarbital in pharmaceutical applications, offering valuable insights for drug delivery design.http://www.sciencedirect.com/science/article/pii/S2949822825003922Bile saltsCritical Micelle Concentration (CMC)Interfacial parametersBinding constantPartition coefficient |
| spellingShingle | Haytham Abuissa Ashraf EL-Hashani Physicochemical investigation of phenobarbital sodium interactions with anionic bile salt micelles: Binding, partitioning, and micellization behavior Next Materials Bile salts Critical Micelle Concentration (CMC) Interfacial parameters Binding constant Partition coefficient |
| title | Physicochemical investigation of phenobarbital sodium interactions with anionic bile salt micelles: Binding, partitioning, and micellization behavior |
| title_full | Physicochemical investigation of phenobarbital sodium interactions with anionic bile salt micelles: Binding, partitioning, and micellization behavior |
| title_fullStr | Physicochemical investigation of phenobarbital sodium interactions with anionic bile salt micelles: Binding, partitioning, and micellization behavior |
| title_full_unstemmed | Physicochemical investigation of phenobarbital sodium interactions with anionic bile salt micelles: Binding, partitioning, and micellization behavior |
| title_short | Physicochemical investigation of phenobarbital sodium interactions with anionic bile salt micelles: Binding, partitioning, and micellization behavior |
| title_sort | physicochemical investigation of phenobarbital sodium interactions with anionic bile salt micelles binding partitioning and micellization behavior |
| topic | Bile salts Critical Micelle Concentration (CMC) Interfacial parameters Binding constant Partition coefficient |
| url | http://www.sciencedirect.com/science/article/pii/S2949822825003922 |
| work_keys_str_mv | AT haythamabuissa physicochemicalinvestigationofphenobarbitalsodiuminteractionswithanionicbilesaltmicellesbindingpartitioningandmicellizationbehavior AT ashrafelhashani physicochemicalinvestigationofphenobarbitalsodiuminteractionswithanionicbilesaltmicellesbindingpartitioningandmicellizationbehavior |