Discovering potential inhibitors against dengue virus NS5 RNA dependent RNA polymerase from local vegetables: a comparative computational study

Discovering potential inhibitors against dengue virus NS5 RNA dependent RNA polymerase from local vegetables: a comparative computational study

Abstract Dengue virus (DENV) remains a global health challenge, necessitating the identification of novel inhibitors against its NS5 RNA-dependent RNA polymerase (RdRp), a critical enzyme for viral replication. This study evaluates the inhibitory potential of 270 phytochemicals from five local veget...

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Main Authors: Md Zahid Hasan, Sheikh Soikot, Md. Motaher Hossain, Maysha Fahmeda Priota, Shanzida Akther, Shianta Jahan, Jahid Bhuyian, Naimur Rahman Sharul, Md. Mosabbir Hossain, Md. Abdulla Al Jubayed, Nilima Rahman, Jannatul Mawya, Naznin Akter, Md. Eram Hosen, Md Omar Faruqe
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Chemistry
Subjects:
Dengue virus
NS5 RNA-dependent RNA polymerase
Plant phytochemicals
Docking
Molecular dynamics simulation
ADMET analysis
Online Access:https://doi.org/10.1007/s44371-025-00198-9
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https://doi.org/10.1007/s44371-025-00198-9

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