Gene regulatory activity associated with polycystic ovary syndrome revealed DENND1A-dependent testosterone production

Abstract Polycystic ovary syndrome (PCOS) is among the most common disorders affecting up to 15% of the menstruating population globally. It is the leading cause of anovulatory infertility and a major risk factor for type 2 diabetes. Elevated testosterone levels are a core endophenotype. Despite tha...

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Bibliographic Details
Main Authors: Laavanya Sankaranarayanan, Kelly J. Brewer, Shauna Morrow, Graham D. Johnson, Alejandro Barrera, Revathy Venukuttan, Ryan Sisk, Andrea Dunaif, Timothy E. Reddy
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62884-7
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