A Comprehensive Revision of Radiation Immunotherapy and the Abscopal Effect in Central Nervous System Metastases: Reassessing the Frontier

A Comprehensive Revision of Radiation Immunotherapy and the Abscopal Effect in Central Nervous System Metastases: Reassessing the Frontier

Seventy years ago, Robin Mole introduced the concept of the abscopal effect to describe a rare phenomenon. This occurs when local radiation triggers an immune-mediated reduction in tumors outside the treated area but within the same organism. Observing this effect has been linked to improved overall...

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Main Authors: Júlia Moscardini-Martelli, Alejandro Rodríguez-Camacho, Jorge Alejandro Torres-Ríos, Juan Marcos Meraz-Soto, José Guillermo Flores-Vázquez, Laura Crystell Hernández-Sánchez, Francisco Javier Lozano-Ruiz, Federico Maldonado-Magos, Dharely Cid-Sánchez, Christian Haydeé Flores-Balcázar, Miguel Ángel Celis-López, Guillermo Axayacatl Gutiérrez-Aceves, Fabiola Flores-Vázquez, Sergio Moreno-Jiménez
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Current Issues in Molecular Biology
Subjects:
abscopal effect
immunotherapy
radiotherapy
radiosurgery
oncology
metastasis
Online Access:https://www.mdpi.com/1467-3045/46/10/658
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