Co-expression and clinical utility of AR-FL and AR splice variants AR-V3, AR-V7 and AR-V9 in prostate cancer

Co-expression and clinical utility of AR-FL and AR splice variants AR-V3, AR-V7 and AR-V9 in prostate cancer

Abstract Background Androgen receptor (AR) splice variants (AR-Vs) have been discussed as a biomarker in prostate cancer (PC). However, some reports question the predictive property of AR-Vs. From a mechanistic perspective, the connection between AR full length (AR-FL) and AR-Vs is not fully underst...

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Main Authors: Neele Wüstmann, Konstantin Egon Seifert, Verena Humberg, Julia Vieler, Norbert Grundmann, Julie Steinestel, Dorothee Tiedje, Stefan Duensing, Laura-Maria Krabbe, Martin Bögemann, Andres Jan Schrader, Christof Bernemann, Katrin Schlack
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Biomarker Research
Subjects:
Androgen receptor
Androgen receptor splice variants
Androgen receptor targeted agents
Biomarker
Circulating tumor cells
Liquid biopsy
Online Access:https://doi.org/10.1186/s40364-023-00481-w
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https://doi.org/10.1186/s40364-023-00481-w

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