Neurotransmitters: an emerging target for therapeutic resistance to tumor immune checkpoint inhibitors

Neurotransmitters: an emerging target for therapeutic resistance to tumor immune checkpoint inhibitors

Abstract The critical role of neurotransmitters in the resistance to tumor immune checkpoint inhibitor (ICI) is becoming increasingly significant in therapeutic contexts. ICIs work by enhancing antitumor immunity through the blockade of the PD-1/PD-L1 and CTLA-4 pathways. However, only 20% of patien...

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Bibliographic Details
Main Authors: Jiyuan Yang, Yu Wu, Xinhui Lv, Sicong Liu, Ziwen Yuan, Yafang Chen, Xiangyu Ding, Zhong Li, Xudong Wang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Molecular Cancer
Subjects:
Neurotransmitters
Immune checkpoint inhibitors
Tumor microenvironment
Drug resistance
Immunotherapy
Online Access:https://doi.org/10.1186/s12943-025-02413-8
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https://doi.org/10.1186/s12943-025-02413-8

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