Total Intramuscular Fat Fraction of Thigh Muscles as a Predictor of Nusinersen Efficacy in Pediatric SMA Type II and III

Total Intramuscular Fat Fraction of Thigh Muscles as a Predictor of Nusinersen Efficacy in Pediatric SMA Type II and III

<b>Background/Objectives</b>: Nusinersen is a disease-modifying drug for spinal muscular atrophy (SMA) that improves motor function. However, its effects on the skeletal muscles remain unclear. This study aimed to assess the intramuscular fat fraction in patients with SMA types II and II...

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Bibliographic Details
Main Authors: Kiiko Iketani, Hiroyuki Awano, Hiromi Hashimura, Shoko Sonehara, Hiroaki Hanafusa, Yoshinori Nambu, Hisahide Nishio, Kandai Nozu, Ryosuke Bo
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Diagnostics
Subjects:
spinal muscular atrophy
muscle magnetic resonance imaging
nusinersen
lipid metabolism
biomarker
Online Access:https://www.mdpi.com/2075-4418/15/6/753
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