Metformin induces apoptosis in pituitary-derived folliculostellate cells via the IL-6/ERK pathway

Metformin induces apoptosis in pituitary-derived folliculostellate cells via the IL-6/ERK pathway

Abstract Purpose The aim of this study was to investigate the function and regulatory mechanism of Interleukin-6 (IL-6) in pituitary-derived folliculostellate (PDFS) cells and to explore the mechanism of metformin against PDFS cells growth through IL-6. Methods Immunohistochemical staining was condu...

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Bibliographic Details
Main Authors: Xin Wang, Siyuan Li, Dong Fan, Yuyou Luo, Huitong Chen, Zhongyu Wang, Xingyi Yuan, Jing Liu, Zongming Wang
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Oncology
Subjects:
IL-6
PD-L1
Non-functioning pituitary adenoma
Metformin
Apoptosis
Online Access:https://doi.org/10.1007/s12672-025-02372-y
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https://doi.org/10.1007/s12672-025-02372-y

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