Dynamics of amylopectin granule accumulation during the course of chronic Toxoplasma infection is linked to intra-cyst bradyzoite replication

Dynamics of amylopectin granule accumulation during the course of chronic Toxoplasma infection is linked to intra-cyst bradyzoite replication

ABSTRACT The contribution of amylopectin granules (AG), a branched chain storage homopolymer of glucose, to the maintenance and progression of the chronic Toxoplasma gondii infection has remained undefined. Here, we describe the role of AG in the physiology of encysted bradyzoites using a purpose-de...

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Bibliographic Details
Main Authors: Aashutosh Tripathi, Ryan W. Donkin, Joy S. Miracle, Robert D. Murphy, Matthew S. Gentry, Abhijit Patwardhan, Anthony P. Sinai
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mSphere
Subjects:
Toxoplasma gondii
amylopectin
bradyzoite
chronic infection
mitochondrial metabolism
restriction checkpoint
Online Access:https://journals.asm.org/doi/10.1128/msphere.00205-25
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https://journals.asm.org/doi/10.1128/msphere.00205-25

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