Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells

Computational strategies to extract meaningful biological information from multiomics data are in great demand for effective clinical use, particularly in complex immune-mediated disorders. Regulatory T cells (Tregs) are essential for immune homeostasis and self-tolerance, controlling inflammatory a...

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Bibliographic Details
Main Authors:	Alexandre A. S. F. Raposo, Pedro Rosmaninho, Susana L. Silva, Susana Paço, Maria E. Brazão, Ana Godinho-Santos, Yumie Tokunaga-Mizoro, Helena Nunes-Cabaço, Ana Serra-Caetano, Afonso R. M. Almeida, Ana E. Sousa
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-10-01
Series:	Frontiers in Immunology
Subjects:	regulatory T cells inborn errors of immunity translational multiomics chromatin accessibility transcription factor binding whole-genome sequencing
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1458581/full
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Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells

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