Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells

Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells

Computational strategies to extract meaningful biological information from multiomics data are in great demand for effective clinical use, particularly in complex immune-mediated disorders. Regulatory T cells (Tregs) are essential for immune homeostasis and self-tolerance, controlling inflammatory a...

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Main Authors: Alexandre A. S. F. Raposo, Pedro Rosmaninho, Susana L. Silva, Susana Paço, Maria E. Brazão, Ana Godinho-Santos, Yumie Tokunaga-Mizoro, Helena Nunes-Cabaço, Ana Serra-Caetano, Afonso R. M. Almeida, Ana E. Sousa
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
regulatory T cells
inborn errors of immunity
translational multiomics
chromatin accessibility
transcription factor binding
whole-genome sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1458581/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1458581/full

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