Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development.

Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development.

The observation that mice with a selective ablation of the androgen receptor (AR) in Sertoli cells (SC) (SCARKO mice) display a complete block in meiosis supports the contention that SC play a pivotal role in the control of germ cell development by androgens. To delineate the physiological and molec...

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Bibliographic Details
Main Authors: Ariane Willems, Sergio R Batlouni, Arantza Esnal, Johannes V Swinnen, Philippa T K Saunders, Richard M Sharpe, Luiz R França, Karel De Gendt, Guido Verhoeven
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014168&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014168&type=printable

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