Ferroptosis in the tumor microenvironment: mechanisms, advances, and therapeutic perspectives

Ferroptosis is a regulated, non-apoptotic form of cell death marked by the accumulation of iron-dependent lipid peroxides. This process causes rapid rupture of the plasma membrane and the release of intracellular contents. Ferroptosis acts as an intrinsic tumor-suppressive mechanism. It plays a cruc...

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Bibliographic Details
Main Authors: Weijuan Gao, Jiani Tan, Chengtao Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
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Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1650219/full
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