Quantitative micro-CT-derived biomarkers elucidate age-related lung fibrosis in elder mice

Quantitative micro-CT-derived biomarkers elucidate age-related lung fibrosis in elder mice

Abstract Background Idiopathic Pulmonary Fibrosis (IPF), prevalently affecting individuals over 60 years of age, has been mainly studied in young mouse models. The limited efficacy of current treatments underscores the need for animal models that better mimic an aged patient population. We addressed...

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Main Authors: Davide Buseghin, Andrea Grandi, Erica Ferrini, Gino Villetti, Roberta Ciccimarra, Nicola Sverzellati, Andrea Aliverti, Francesca Pennati, Franco Fabio Stellari
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Respiratory Research
Subjects:
Age
Bleomycin model
Lung fibrosis
IPF
Micro-computed tomography
Nintedanib
Online Access:https://doi.org/10.1186/s12931-024-03006-7
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https://doi.org/10.1186/s12931-024-03006-7

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