Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells.

Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells.

<h4>Background and aims</h4>Liver fibrosis is a major cause of morbidity and mortality. It is characterised by excessive extracellular matrix (ECM) deposition from activated hepatic stellate cells (HSCs). Although potentially reversible, treatment remains limited. Understanding how ECM i...

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Main Authors: James Pritchett, Varinder S Athwal, Emma Harvey, Katherine Martin, Jessica Llewellyn, Philip Ireland, Alexander Nicolaides, Martin J Humphries, Nicoletta Bobola, Neil A Hanley, Karen Piper Hanley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0100091
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https://doi.org/10.1371/journal.pone.0100091

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