Independent prognostic significance of tumor budding and poorly differentiated clusters in Brazilian patients with stage II colorectal cancer

Independent prognostic significance of tumor budding and poorly differentiated clusters in Brazilian patients with stage II colorectal cancer

Abstract Background Colorectal cancer (CRC) is the third most commonly diagnosed and the second most fatal cancer worldwide. Tumor budding (TB) and poorly differentiated clusters (PDC) are morphological features with significant prognostic value that may aid therapeutic decisions, particularly in st...

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Main Authors: Monise Tadin Reis, Marcus Matsushita, Wellington Santos, Gustavo Noriz Berardinelli, Valiana Teodoro, Mariana Bisarro dos Reis, Denise Peixoto Guimarães, Rui Manuel Reis
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Surgical and Experimental Pathology
Subjects:
Colorectal cancer
Tumor budding
Poorly differentiated cluster
Prognostic factor
Disease-specific survival
Disease-free survival
Online Access:https://doi.org/10.1186/s42047-025-00196-2
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https://doi.org/10.1186/s42047-025-00196-2

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