Silk fibroin–collagen hydrogel loaded with IGF1-CESCs attenuates intervertebral disk degeneration by accelerating annulus fibrosus healing in rats

Silk fibroin–collagen hydrogel loaded with IGF1-CESCs attenuates intervertebral disk degeneration by accelerating annulus fibrosus healing in rats

Introduction: The self-healing capacity of a damaged annulus fibrosus (AF) leads to intervertebral disk (IVD) degeneration. AF wound treatment is challenging. The combination of biomaterials and stem cell-derived exosomes is a promising wound treatment strategy with significant clinical value.Method...

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Bibliographic Details
Main Authors: Zhiqiang Tian, Zigang Shen, Hong Chen, Ping Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
annulus fibrosus
wound treatment
IGF1
exosome
intervertebral disc
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1552174/full
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