A novel pThr217 tau monoclonal antibody reveals neuropathological heterogeneity in tauopathies

Abstract Tauopathies are a group of clinically and neuropathologically diverse neurodegenerative disorders defined by the abnormal aggregation of tau protein. While tau is normally soluble with limited secondary structure, pathological tau is characterized by hyperphosphorylation and assembly into f...

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Bibliographic Details
Main Authors: Giavanna Paterno, Brach M. Bell, Kimberly-Marie M. Gorion, Stephan Quintin, Stefan Prokop, Benoit I. Giasson
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-04291-y
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