Improved epigenetic age prediction models by combining sex chromosome and autosomal markers

Improved epigenetic age prediction models by combining sex chromosome and autosomal markers

Abstract Background Alterations in epigenetic DNA methylation (DNAm) can be used as an accurate and robust method for biological age prediction. We assessed the feasibility of incorporating sex chromosomal DNAm markers into a six autosomal DNAm CpG marker-based age prediction model, since DNAm-based...

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Bibliographic Details
Main Authors: Zhong Wan, Peter Henneman, Huub C. J. Hoefsloot, Ate D. Kloosterman, Pernette J. Verschure
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Epigenetics & Chromatin
Subjects:
Age prediction
Epigenetics
DNA methylation
Sex chromosome
Random forest regression
Online Access:https://doi.org/10.1186/s13072-025-00606-5
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https://doi.org/10.1186/s13072-025-00606-5

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