<i>CRTAP</i>-Null Osteoblasts Have Increased Proliferation, Protein Secretion, and Skeletal Morphogenesis Gene Expression with Downregulation of Cellular Adhesion

<i>CRTAP</i>-Null Osteoblasts Have Increased Proliferation, Protein Secretion, and Skeletal Morphogenesis Gene Expression with Downregulation of Cellular Adhesion

Type VII osteogenesis imperfecta (OI), caused by recessive <i>CRTAP</i> mutations, is predominantly lethal in the first year of life. Due to its early lethality, little is known about bone dysplasia mechanism. RNA-seq analysis of differentiated osteoblasts of siblings with a non-lethal h...

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Bibliographic Details
Main Authors: Aileen M. Barnes, Apratim Mitra, Marianne M. Knue, Alberta Derkyi, An Dang Do, Ryan K. Dale, Joan C. Marini
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
cartilage-associated protein
osteogenesis imperfecta
3-hydroylation complex
Online Access:https://www.mdpi.com/2073-4409/14/7/518
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