A dual-drug strategy to enhance the function of cryopreserved ovaries by promoting revascularization and inhibiting follicle over-activation

A dual-drug strategy to enhance the function of cryopreserved ovaries by promoting revascularization and inhibiting follicle over-activation

Abstract Background Ovarian tissue cryopreservation and transplantation (OTCT) is a promising approach for fertility preservation. However, significant follicle loss after transplantation challenges long-term reproductive recovery. Although primordial follicle loss and ischemic damage are known cont...

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Main Authors: Lingyu Li, Jian Yang, Longzhong Jia, Jing Liang, Kaixin Cheng, Xuebing Yang, Lu Mu, Ge Wang, Kaiying Geng, Qiuxian Hu, Xueqiang Xu, Zhen Li, Guoliang Xia, Ting Guo, Jiawei Zhang, Yan Zhang, Hua Zhang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Reproductive Biology and Endocrinology
Subjects:
Ovarian cryopreservation
3D high resolution imaging
Tip cell
Long-term fertility preservation
Primordial follicle activation
Online Access:https://doi.org/10.1186/s12958-025-01422-y
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https://doi.org/10.1186/s12958-025-01422-y

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