A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein synthesis regulation

A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein synthesis regulation

Abstract Progeria syndromes are very rare, incurable premature aging conditions recapitulating most aging features. Here, we report a whole genome, multiparametric CRISPR screen, identifying 43 genes that can rescue multiple cellular phenotypes associated with progeria. We implement the screen in fi...

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Main Authors: Sophia Y. Breusegem, Jack Houghton, Raquel Romero-Bueno, Adrián Fragoso-Luna, Katherine A. Kentistou, Ken K. Ong, Anne F. J. Janssen, Nicholas A. Bright, Christian G. Riedel, John R. B. Perry, Peter Askjaer, Delphine Larrieu
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56916-5
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https://doi.org/10.1038/s41467-025-56916-5

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