DNA methylation variations of DNA damage response in glioblastoma: NSUN5 modulates tumor-intrinsic cytosolic DNA-sensing and microglial behavior

DNA methylation variations of DNA damage response in glioblastoma: NSUN5 modulates tumor-intrinsic cytosolic DNA-sensing and microglial behavior

Abstract Background Variations in DNA methylation within the DNA damage response (DDR) mechanism could have significant implications for glioma prognosis and immune responses. This study aimed to explore the global DNA methylation landscape of DDR genes in gliomas and identify key epigenetically reg...

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Main Authors: An-an Yin, Yan Yao, Yi-feng Liu, Yu-sha Ji, Ya-long He, Tian-chi Ma, Wen-heng Guo, Amandine Etcheverry, Marc Aubry, Jean Mosser, Wei Lin, Yuan-ming Wu, Kun Chen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Glioma
DNA damage response
DNA methylation
Cytosolic DNA sensing
NSUN5
Online Access:https://doi.org/10.1186/s12967-025-06360-2
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https://doi.org/10.1186/s12967-025-06360-2

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