Dynamic predictive power of TP53 signatures in breast cancer prognosis: Pre- and post-neoadjuvant chemotherapy insights

Dynamic predictive power of TP53 signatures in breast cancer prognosis: Pre- and post-neoadjuvant chemotherapy insights

Background: The TP53 signature determined using a biopsy specimen before neoadjuvant chemotherapy (pre-NAC biopsy specimens) predicts NAC response and prognosis in breast cancer. We aimed to compare the clinical utility of the TP53 signature determined using pre-NAC biopsy specimens and surgical spe...

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Bibliographic Details
Main Authors: Keiju Sasaki, Shin Takahashi, Kota Ouchi, Hidekazu Shirota, Nobuaki Sato, Kouji Kaneko, Norikazu Masuda, Fumiyoshi Fujishima, Satoko Sato, Chikashi Ishioka
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Translational Oncology
Subjects:
Breast cancer
Neoadjuvant chemotherapy
Gene expression profile
TP53
Clinical biomarker
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001299
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http://www.sciencedirect.com/science/article/pii/S1936523325001299

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