Mechanisms of DNA Damage Recognition by UDG and PARP1 in the Nucleosome

Mechanisms of DNA Damage Recognition by UDG and PARP1 in the Nucleosome

The DNA base-excision repair (BER) pathway shares the second part of its enzymatic chain with the single-strand break (SSB) repair pathway. BER is initiated by a glycosylase, such as UDG, while SSBR is initiated by the multifunctional enzyme PARP1. The very early steps in the identification of the D...

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Bibliographic Details
Main Authors: Safwen Ghediri, Parvathy A. P. Sarma, Vinnarasi Saravanan, Corinne Abbadie, Ralf Blossey, Fabrizio Cleri
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biomolecules
Subjects:
DNA damage
DNA repair
Single-strand break
Uracil base excision
Nucleosome
Molecular dynamics
Online Access:https://www.mdpi.com/2218-273X/15/5/649
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