Nonmuscle Myosin-2B Regulates Apical Cortical Mechanics, ZO-1 Dynamics and Cell Size in MDCK Epithelial Cells

Nonmuscle Myosin-2B Regulates Apical Cortical Mechanics, ZO-1 Dynamics and Cell Size in MDCK Epithelial Cells

In epithelial cells, nonmuscle myosin-2B (NM2B) shows a cortical localization and is tethered to tight junctions (TJs) and adherens junctions (AJs) by the junctional adaptor proteins cingulin and paracingulin. MDCK cells knock-out (KO) for cingulin show decreased apical membrane cortex stiffness and...

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Bibliographic Details
Main Authors: Marine Maupérin, Niklas Klatt, Thomas Glandorf, Thomas Di Mattia, Isabelle Méan, Andreas Janshoff, Sandra Citi
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
nonmuscle myosin-2B
ZO-1
cadherin
actin
cortex
cell size
Online Access:https://www.mdpi.com/2073-4409/14/15/1138
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