Engineering Bifunctional Calcium Alendronate Gene‐Delivery Nanoneedle for Synergistic Chemo/Immuno‐Therapy Against HER2 Positive Ovarian Cancer

Engineering Bifunctional Calcium Alendronate Gene‐Delivery Nanoneedle for Synergistic Chemo/Immuno‐Therapy Against HER2 Positive Ovarian Cancer

Abstract Ovarian cancer is the most lethal gynecological malignancy. Most patients are diagnosed at an advanced stage with widespread peritoneal dissemination and ascites. Bispecific T‐cell engagers (BiTEs) have demonstrated impressive antitumor efficacy in hematological malignancies, but the clinic...

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Bibliographic Details
Main Authors: Guochuang Chen, Leli Zeng, Bo Bi, Xiuyu Huang, Miaojuan Qiu, Ping Chen, Zhi‐Ying Chen, Yulong He, Yihang Pan, Yu Chen, Jing Zhao
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Advanced Science
Subjects:
alendronate
bispecific T‐cell engager
gene delivery
immunotherapy
ovarian cancer
Online Access:https://doi.org/10.1002/advs.202204654
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https://doi.org/10.1002/advs.202204654

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