Transient Receptor Potential Vanilloid 4 Knockdown Decreases Extracellular Matrix Synthesis via Autophagy Suppression in the Rat Intervertebral Disc

Transient Receptor Potential Vanilloid 4 Knockdown Decreases Extracellular Matrix Synthesis via Autophagy Suppression in the Rat Intervertebral Disc

ABSTRACT Background Transient receptor potential vanilloid 4 (TRPV4) has been identified as a Ca2+‐permeable channel and is activated under physiological mechanical stimulation in disc nucleus pulposus (NP) cells. Meanwhile, the Ca2+‐dependent AMP‐activated protein kinase (AMPK)/mTOR pathway activat...

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Main Authors: Tomoya Matsuo, Yoshiki Takeoka, Takashi Yurube, Takeru Tsujimoto, Yutaro Kanda, Kunihiko Miyazaki, Hiroki Ohnishi, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Ryosuke Kuroda, Kenichiro Kakutani
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:JOR Spine
Subjects:
autophagy
extracellular matrix
intervertebral disc
nucleus pulposus cell
RNA interference (RNAi)
spine
Online Access:https://doi.org/10.1002/jsp2.70046
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https://doi.org/10.1002/jsp2.70046

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