Integrating multi-omics to unveil PSMD12 as a critical gene in promoting brain metastases of lung adenocarcinoma

Integrating multi-omics to unveil PSMD12 as a critical gene in promoting brain metastases of lung adenocarcinoma

Abstract Background Brain metastases (BM) remain the leading cause of death in patients with lung adenocarcinoma (LUAD) despite the availability of comprehensive therapeutics. This study aimed to systematically identify crucial genes associated with BM in patients with LUAD, and develop a heuristic...

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Main Authors: Xin Li, Juxuan Zhang, Meng Zhang, Wenbin Jiang, Dexin Jia, Ruxiong Wang, Hao Li, Zhihui Wang, Yixin Liu, Lefan Tang, Jiaxing Deng, Wenyuan Zhao, Yan Yu, Shilong Liu, Lishuang Qi
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Lung adenocarcinoma
Brain metastasis
In vitro blood–brain barrier
TF regulatory network
PSMD12
Online Access:https://doi.org/10.1186/s12967-025-06680-3
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https://doi.org/10.1186/s12967-025-06680-3

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