Lysophosphatidylcholine promoting α-Synuclein aggregation in Parkinson’s disease: disrupting GCase glycosylation and lysosomal α-Synuclein degradation

Lysophosphatidylcholine promoting α-Synuclein aggregation in Parkinson’s disease: disrupting GCase glycosylation and lysosomal α-Synuclein degradation

Abstract In Parkinson’s Disease (PD), elevated serum lysophosphatidylcholine (LPC) levels correlate with disease progression. However, the mechanisms by which abnormal LPC elevation contributes to PD-related neurotoxicity remain poorly understood. This study aims to investigate the pathogenic role o...

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Main Authors: Chunyan Mu, Kaiquan Shao, Mingyu Su, Yurong Guo, Yuxiang Qiu, Ruiao Sun, Sihan Sun, Yaoyu Sun, Chenkai Liu, Wei Wang, Xiaoling Qin, Chuanxi Tang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-00902-7
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https://doi.org/10.1038/s41531-025-00902-7

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