Intravenous vs. Oral Dose Comparison of Ibuprofen and Tramadol Combinations—Enantiomers, Metabolite, Linearity, and Sex-Related Effects: A Pharmacokinetics Randomized Clinical Trial

Intravenous vs. Oral Dose Comparison of Ibuprofen and Tramadol Combinations—Enantiomers, Metabolite, Linearity, and Sex-Related Effects: A Pharmacokinetics Randomized Clinical Trial

<b>Background/Objectives:</b> Using a combination of analgesics allows for the use of lower doses of each, therefore, lowering risk of side effects. The study aims to estimate the bioavailability (pharmacokinetics of enantiomers and metabolites, as well as linearity and sex-related effec...

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Main Authors: Carmen Portolés-Díez, María Rosario Salas-Butrón, Ana Ascaso-del-Rio, Ana B. Rivas-Paterna, Leonor Laredo-Velasco, Carlos Calandria, Nuria Sanz, Annik Bergeron, Luis Santé, Emilio Vargas-Castrillón, Antonio Portolés-Pérez
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceuticals
Subjects:
O-desmethyl-Tramadol
bioavailability
analgesics association
opioids
non-steroidal analgesics
clinical trial
Online Access:https://www.mdpi.com/1424-8247/18/3/331
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