Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway

Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway

BackgroundPulmonary arterial hypertension (PAH) exhibits significant gender differences in prognosis, with male patients typically showing worse outcomes than females. These disparities may stem from differences in androgen receptor expression and activity. Clinical studies suggest that the androgen...

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Bibliographic Details
Main Authors: Jiayan Sun, Jiancheng Lin, Di Yin, Zetao Pan, Yuheng Ye, Yi Wang, Xiaowan Wang, Qiang Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary arterial hypertension
androgen receptor
Notch3
Hes5
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1572489/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1572489/full

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