Integrative analysis and experimental validation identify the role of CD44 and Nucleolin in regulating gliogenesis following spinal cord injury

Integrative analysis and experimental validation identify the role of CD44 and Nucleolin in regulating gliogenesis following spinal cord injury

Abstract Spinal cord injury (SCI) triggers a complex cascade of cellular and molecular responses, yet the complex cellular communication remains incompletely understood. This study explored how intercellular communication contributes to the activation of microglia and astrocytes after SCI. Here, we...

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Bibliographic Details
Main Authors: Ming Shi, Yazhou Sun, Lu Ding, Xinyue Li, Qi Xu, Fuxin Wei, Tianshun Gao, David Y. B. Deng
Format: Article
Language:English
Published: SpringerOpen 2025-08-01
Series:Cell Regeneration
Subjects:
Spinal cord injury
ScRNA-seq/snRNA-seq analysis
Ligand-receptor interaction
Inflammation
Gliogenesis
Online Access:https://doi.org/10.1186/s13619-025-00253-x
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https://doi.org/10.1186/s13619-025-00253-x

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