Extreme wrinkling of the nuclear lamina is a morphological marker of cancer

Extreme wrinkling of the nuclear lamina is a morphological marker of cancer

Abstract Nuclear atypia is a hallmark of cancer. A recent model posits that excess surface area, visible as folds/wrinkles in the lamina of a rounded nucleus, allows the nucleus to take on diverse shapes with little mechanical resistance. Whether this model is applicable to normal and cancer nuclei...

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Main Authors: Ting-Ching Wang, Christina R. Dollahon, Sneha Mishra, Hailee Patel, Samere Abolghasemzade, Ishita Singh, Vilmos Thomazy, Daniel G. Rosen, Vlad C. Sandulache, Saptarshi Chakraborty, Tanmay P. Lele
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-024-00775-8
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https://doi.org/10.1038/s41698-024-00775-8

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